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Value-of-Information Diagnostics in Clinical Testing: A Decision-Theoretic Framework for Cost-Constrained Test Selection
In the evolving landscape of clinical diagnostics, where resource limitations increasingly dictate testing protocols, the integration of value-of-information (VoI) principles within decision-theoretic models offers a transformative approach to optimizing test selection. This conceptual manuscript proposes a novel framework that embeds VoI diagnostics into cost-constrained clinical testing environments, enabling healthcare providers to prioritize tests based on their informational yield relative to economic burdens. Drawing from decision theory, the framework articulates a structured methodology for evaluating diagnostic tests not merely by accuracy but by their capacity to reduce uncertainty in clinical decision-making under budgetary constraints. Key components include a layered architecture that incorporates probabilistic assessments of test outcomes, utility functions for health gains, and iterative feedback mechanisms to refine selections dynamically. Theoretical formulas are introduced to interpret risk propagation in test cascades and decision confidence amid cost thresholds. By synthesizing recent literature on VoI in healthcare, this work highlights how such a framework could mitigate over-testing, enhance resource allocation, and align diagnostic strategies with value-based care paradigms. While conceptual in nature, the implications extend to infrastructural designs in AI-supported healthcare systems, fostering more equitable and efficient clinical pathways. Ultimately, this decision-theoretic lens reframes test selection as an optimization problem, balancing informational value against fiscal realities in diagnostic workflows.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 January 2025 | Article: 44

Remote Rehabilitation Progress Quantification: A Smartphone Motion Primitive Framework for Interpretable Recovery Tracking
In the evolving landscape of digital health, remote rehabilitation emerges as a pivotal strategy to enhance patient recovery outside traditional clinical settings. This conceptual manuscript introduces a novel framework leveraging smartphone-embedded sensors to quantify rehabilitation progress through motion primitives—fundamental movement units that enable interpretable tracking of recovery trajectories. By decomposing complex rehabilitative exercises into atomic motion elements, the proposed system facilitates granular analysis of patient adherence, functional improvements, and potential deviations in remote environments. Drawing on theoretical principles from biomechanics, signal processing, and human-computer interaction, we outline an architectural design that integrates real-time data capture, primitive extraction, and interpretive visualization without relying on empirical validation or machine learning models. The framework emphasizes interpretability by mapping primitives to clinical recovery milestones, thereby supporting clinicians in remote decision-making. Key conceptual elements include hierarchical primitive decomposition, temporal alignment mechanisms, and feedback loops for progress quantification. Formulas are presented to model decision confidence in primitive-based assessments and resource allocation for remote monitoring. This approach addresses gaps in current remote rehabilitation paradigms by prioritizing accessibility via ubiquitous smartphones, reducing dependency on specialized wearables, and enhancing patient empowerment through transparent recovery insights. Ultimately, the framework posits a scalable infrastructure for interpretable recovery tracking, fostering equitable access to rehabilitation analytics in diverse socioeconomic contexts. While theoretical, it lays the groundwork for future implementations in post-surgical, neurological, and musculoskeletal recovery scenarios.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 January 2025 | Article: 45

Multi-Agent Coordination for Operating Room Turnover: A Constraint-Based Optimization Blueprint
Operating room (OR) turnover represents a critical bottleneck in surgical workflows, where delays in transitioning between procedures can cascade into inefficiencies, increased costs, and compromised patient care. This conceptual manuscript introduces a blueprint for multi-agent coordination grounded in constraint-based optimization to streamline OR turnover processes. Drawing from clinical AI architectures and healthcare analytics infrastructures, we propose the constraint-adaptive multi-agent turnover orchestrator (CAMATO). This theoretical framework integrates autonomous agents for real-time task allocation, resource synchronization, and procedural handoffs. CAMATO leverages interoperability frameworks and decision support pipelines to model turnover as a constrained optimization problem, incorporating variables such as staff availability, equipment sterilization cycles, and environmental constraints. The architecture emphasizes governance mechanisms to monitor agent interactions and mitigate coordination failures, ensuring alignment with electronic health record (EHR) intelligence ecosystems. Through interpretive formulas, we conceptualize risk propagation in agent networks, decision confidence under uncertainty, and resource allocation dynamics. This blueprint highlights the potential for enhanced clinical workflow integration without empirical validation, focusing on theoretical implications for scalable, resilient OR management. By synthesizing recent literature on AI-driven healthcare systems, we outline pathways for future architectural refinements in high-stakes clinical environments.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 January 2025 | Article: 46

Preventive Care Recommendations via Benefit–Burden Trade-Offs: A Patient-Centered Utility Framework
 In the evolving landscape of artificial intelligence (AI) for healthcare, patient-centered approaches are essential to balance preventive care benefits against potential burdens. This conceptual manuscript introduces a novel framework for generating preventive care recommendations through explicit benefit–burden trade-offs, prioritizing individual patient utilities. Drawing from clinical AI architectures, healthcare analytics infrastructures, and electronic health record (EHR) intelligence ecosystems, we propose the patient utility trade-off architecture (PUTA). This multi-layered system integrates decision support pipelines with AI governance and interoperability frameworks. PUTA employs utility-based modeling to quantify benefits such as improved health outcomes and burdens like treatment side effects or resource demands, facilitating personalized recommendations in preventive settings. Theoretical formulas capture decision confidence and burden propagation, ensuring interpretive insights into system dynamics without empirical validation. We synthesize recent literature on clinical workflow integration and monitoring systems, highlighting how PUTA addresses gaps in patient-centered AI deployment. By emphasizing infrastructural uniqueness, including adaptive feedback topologies, this framework advances equitable preventive care. Implications for governance in diverse clinical environments underscore the need for robust data exchange and ethical monitoring, positioning PUTA as a foundational tool for future AI-driven healthcare systems.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 January 2025 | Article: 47

Social Determinants Integration Without Proxy Leakage: A Causal Design Pattern for Equity-Preserving Modeling
The integration of social determinants of health (SDOH) into artificial intelligence (AI) models for healthcare systems presents a critical challenge in preserving equity while avoiding proxy leakage, where sensitive attributes inadvertently influence predictions through correlated variables. This conceptual manuscript proposes a novel causal design pattern that enables the seamless incorporation of SDOH data into clinical AI architectures without compromising fairness. By leveraging causal inference principles, the pattern mitigates leakage pathways in decision support pipelines, ensuring that equity-preserving modeling aligns with governance frameworks in electronic health record (EHR) intelligence ecosystems. We outline a unique architectural framework, the causal equity orchestrator (CEO), which features layered causal nodes, feedback loops for drift detection, and interpretive formulas for risk propagation and decision confidence. Drawing on a synthesis of recent literature from clinical AI system architectures and healthcare analytics infrastructures, this work emphasizes theoretical implications for interoperability in diverse clinical workflows. The design promotes robust, bias-resistant integration, fostering equitable outcomes in population health analytics without empirical validation. Ultimately, this pattern offers a blueprint for AI developers and health informatics specialists to construct systems that uphold ethical standards in SDOH-driven modeling, addressing disparities in underserved communities through principled causal mechanisms.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 January 2025 | Article: 48

Wearable Calibration Transfer Across Device Generations: A Generalization Framework for Clinical Sensing
The rapid evolution of wearable sensor hardware across successive device generations introduces systematic signal drift that undermines the reliability of clinical-grade physiological sensing in real-world healthcare ecosystems. This conceptual systems research article proposes a novel architectural solution to the persistent challenge of calibration transfer without empirical retraining or device-specific fine-tuning. We introduce the cross-generation calibration orchestration and transfer infrastructure (CG-COTI) — a theoretical multi-layer generalization framework specifically engineered for clinical sensing. CG-COTI establishes a device-agnostic calibration lattice that propagates standardized physiological representations across hardware generations through orchestrated metadata-driven mapping, federated drift governance, and closed-loop intelligence layers. Three interpretive conceptual formulations are advanced: a risk-propagation index capturing cumulative sensor drift in multi-generational deployments, a decision-confidence decay function under uncalibrated generational shifts, and a governance-load equilibrium equation balancing monitoring burden with clinical safety. Positioned within existing EHR intelligence ecosystems and decision-support pipelines, CG-COTI offers a scalable architectural blueprint for seamless interoperability, regulatory-compliant deployment, and sustained analytical fidelity. By anchoring calibration transfer within clinical governance and workflow integration models, the framework eliminates the need for repeated device-specific recalibration while preserving signal integrity essential for continuous patient monitoring, early deterioration detection, and precision therapeutics. This purely conceptual architecture advances the theoretical foundations of wearable-enabled healthcare systems, providing a reusable infrastructural scaffold for next-generation clinical sensing deployments across heterogeneous device fleets.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 July 2025 | Article: 49

Demand-Shock Detection for Hospital Supply Chains: A Resilience Analytics Blueprint for Critical Consumables
Hospital supply chains face unprecedented vulnerabilities from demand shocks, such as pandemics or natural disasters, which disrupt the availability of critical consumables like personal protective equipment and medications. This conceptual manuscript proposes a resilience analytics blueprint leveraging artificial intelligence (AI) to detect and mitigate these shocks in healthcare systems. Drawing on clinical AI architectures, healthcare analytics infrastructures, and electronic health record (EHR) intelligence ecosystems, we introduce the demand-shock adaptive resilience network (DSARN), a novel framework for proactive monitoring and orchestration. DSARN integrates decision support pipelines with AI governance mechanisms to enable real-time anomaly detection without empirical data or model training. Key components include layered interoperability frameworks for data exchange across hospital nodes and workflow integration models that prioritize critical consumables. Conceptual formulas illustrate risk propagation through supply networks and governance load on monitoring systems. By synthesizing recent literature on AI deployment in healthcare, this blueprint emphasizes theoretical infrastructures for enhancing supply chain resilience, addressing interoperability challenges, and ensuring ethical governance. The architecture fosters adaptive feedback topologies to anticipate disruptions, offering a pathway for hospitals to build robust analytics ecosystems. Ultimately, DSARN provides a theoretical foundation for transforming reactive supply management into predictive resilience, safeguarding patient care amid volatility.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 July 2025 | Article: 50

Alarm Fatigue Mitigation Under Safety Constraints: A Context-Aware Suppression Design Framework
Alarm fatigue in healthcare settings poses significant risks to patient safety, arising from excessive, non-actionable alerts that desensitize clinicians. This conceptual manuscript introduces a novel framework for mitigating alarm fatigue through context-aware suppression mechanisms, while rigorously adhering to safety constraints. Drawing on theoretical principles from systems engineering, human factors, and artificial intelligence, we propose the safety-integrated context-aware suppression topology (SICAST), a multi-layered architecture designed to dynamically filter alarms based on real-time contextual data such as patient physiology, environmental factors, and clinician workload. The framework incorporates feedback loops for continuous adaptation, ensuring suppression decisions prioritize risk minimization without compromising vigilance. Key components include a context aggregation layer, a suppression decision engine governed by safety thresholds, and an audit trail for governance. Interpretive formulas model risk propagation under suppression and decision confidence amid constraints. By synthesizing recent literature, we highlight how SICAST addresses gaps in existing approaches, such as static thresholding and a lack of contextual integration. This work advances conceptual designs for AI-driven healthcare systems, emphasizing infrastructural resilience and ethical deployment. Implications for system orchestration in critical care underscore the need for balanced alarm management to enhance patient outcomes and reduce clinician burden.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 July 2025 | Article: 51

Home Monitoring Adherence Verification Using Passive Signals: A Robust Missingness-Informed Detection Framework
The rapid evolution of artificial intelligence in healthcare has spotlighted the need for reliable home monitoring systems to verify patient adherence to prescribed regimens. This conceptual manuscript introduces a novel framework for adherence verification leveraging passive signals—such as ambient sensors, wearables, and environmental data—while robustly addressing data missingness. Traditional approaches often falter in real-world deployments due to intermittent signal capture, leading to inaccurate assessments and compromised clinical decisions. We propose the missingness-resilient adherence orchestration network (MRAON), an architectural construct that integrates multi-modal passive signals through layered processing, incorporating missingness-informed imputation strategies and adaptive detection mechanisms. The framework emphasizes theoretical infrastructure for signal fusion, risk propagation modeling, and governance of decision confidence under uncertainty. By synthesizing recent literature on passive monitoring and missing data handling, we delineate how MRAON enhances verification robustness without relying on empirical evaluations. Key conceptual formulas capture dynamics like decision confidence as a function of missingness severity and monitoring burden influenced by resource allocation. This work advances theoretical discourse in AI-driven healthcare analytics, offering a blueprint for scalable, ethical home monitoring systems that prioritize patient autonomy and data integrity. Ultimately, MRAON paves the way for future integrations in chronic disease management, reducing healthcare burdens through intelligent, passive adherence detection.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 July 2025 | Article: 52

Maternal Risk Stratification from Prenatal Care Trajectories: A Continuity-Aware Modeling Framework for Preventable Harm
Maternal healthcare faces escalating challenges in identifying preventable harms during pregnancy, where fragmented prenatal care trajectories often obscure emerging risks. This conceptual manuscript introduces a novel continuity-aware modeling framework designed to stratify maternal risks by integrating longitudinal care trajectories into a cohesive analytical architecture. Drawing on theoretical principles from systems engineering and healthcare informatics, the framework emphasizes the orchestration of prenatal data streams to enhance risk detection without relying on empirical datasets or performance metrics. Key components include modular layers for trajectory mapping, continuity assessment, and harm anticipation, supported by interpretive formulas that model risk propagation and decision confidence. By prioritizing infrastructural resilience and governance integration, this approach theorizes improved alignment between clinical workflows and preventive strategies, potentially mitigating disparities in maternal outcomes. The discussion synthesizes literature on machine learning applications in perinatal risk prediction and midwifery continuity models, highlighting architectural innovations for sustainable deployment in diverse healthcare environments. Ultimately, this framework advocates for a paradigm shift toward proactive, continuity-centric systems in maternal risk management, fostering theoretical advancements in AI-driven healthcare analytics.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 July 2025 | Article: 52

Near–Real-Time Health Inequity Detection: A Disparity Surveillance Framework for Service Access Monitoring
Health inequities persist as a critical challenge in modern healthcare systems, often manifesting through unequal access to essential services. This conceptual manuscript introduces a novel disparity surveillance framework designed for near-real-time detection of health inequities in service access monitoring. By integrating artificial intelligence-driven analytics with infrastructural orchestration, the framework emphasizes proactive identification of access disparities across diverse populations. Drawing from theoretical foundations in public health equity and AI governance, we propose the near-real-time inequity monitoring architecture (NRIMA). This layered system incorporates data ingestion, disparity analytics, and adaptive feedback mechanisms to enhance surveillance efficacy. Without relying on empirical data or model training, the architecture focuses on theoretical constructs such as risk propagation models and decision confidence formulas to interpret potential inequities. Key components include modular layers for real-time signal processing and governance-compliant orchestration, ensuring ethical deployment in clinical and community settings. The framework’s unique feedback topology promotes dynamic adjustments to monitoring protocols, mitigating biases in service allocation. Through literature synthesis, we highlight alignments with existing AI applications in health surveillance while advancing conceptual uniqueness. Ultimately, this work contributes to theoretical discourse on AI-enabled equity in healthcare, advocating for infrastructural innovations that prioritize inclusivity and timeliness in disparity detection.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 10 July 2025 | Article: 53

Sequence Learning Model for Predicting Repeat Diagnostic Imaging Orders Using Prior Imaging History, Symptom Documentation, Specialist Recommendations, Ordering Physician Behavior, and Recent Test Results
Repeat diagnostic imaging is a major driver of healthcare costs, radiation exposure, workflow burden, and downstream follow-up from incidental findings. Its occurrence often follows recognizable patterns shaped by prior imaging, persistent symptoms, specialist advice, recent results, and provider ordering habits. Current utilization management tools often respond after an imaging order has already been placed or rely on static appropriateness rules. They therefore miss opportunities to anticipate repeat ordering risk before the clinician reaches the final order-entry step. This manuscript proposes a sequence learning model that could predict the probability of a repeat diagnostic imaging order within a future clinical window. The model would integrate prior imaging history, symptom documentation, specialist recommendations, ordering physician behavior, and recent test results. The conceptual model would use a recurrent neural network or Transformer encoder to process temporally ordered imaging and clinical events. Structured radiology information system data would be combined with natural language processing features from clinical notes and consult documentation, physician-level ordering context, and recent laboratory or imaging-result signals. Conceptually, the model would forecast whether a repeat CT, MRI, ultrasound, or related diagnostic imaging order is likely to occur. It would also identify major contextual drivers so that the prediction could support pre-emptive review, alternative care suggestions, or guideline-aligned follow-up. A sequence learning model for repeat imaging prediction could function as a safety-and-value layer within radiology workflow. It could reduce unsupported imaging variation while preserving clinically indicated follow-up and surveillance.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 25 February 2025 | Article: 101

Explainable Risk Stratification Model for Prioritizing Case Management Referrals Using Prior Utilization, Chronic Disease Burden, Social Needs Documentation, Missed Appointments, and Care Gap Indicators
Case management programs are intended to reduce avoidable utilization and improve coordination for patients with complex medical, social, and engagement needs. Because case management capacity is limited, health systems need prioritization tools that are both clinically sensible and transparent. Existing referral methods often rely on clinician judgment, simple utilization thresholds, or proprietary risk scores that provide limited explanation. These approaches may overlook social needs, missed appointments, and care gaps that shape patient complexity and influence whether an intervention is feasible. This article proposes an explainable machine learning model that stratifies patients by risk of future high utilization and provides patient-specific reasoning. The model is designed around prior utilization, chronic disease burden, social needs documentation, missed appointments, and care gap indicators. The conceptual architecture uses a gradient-boosted classification model with a SHAP-based post-hoc explanation layer. The model would output both a risk score and a ranked list of contributing factors for each patient considered for case management referral. Conceptually, the model would identify patients who may benefit from case management and explain why each patient was prioritized. These explanations could help case managers tailor outreach, match patients to intervention pathways, and distinguish medical complexity from social instability or disengagement. An explainable risk stratification model could turn a blind referral process into a transparent, clinically sensible prioritization workflow. Its value would depend on careful implementation, fairness monitoring, and alignment with real case manager decision-making.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 25 February 2025 | Article: 102

Probabilistic Record Linkage and Machine Learning Model for Detecting Duplicate Patient Records Using Demographic Similarity, Address Variation, Encounter History, Insurance Identifiers, and Clinical Pattern Matching
Duplicate patient records are a pervasive problem in electronic health records, endangering patient safety and inflating healthcare costs. In EHR-driven health systems, identity fragmentation can separate medications, allergies, diagnoses, laboratory results, and prior encounters across more than one record. Traditional probabilistic linkage relies on manual tuning of weights for demographic attributes and cannot fully exploit temporal address changes, insurance identifiers, or clinical patterns. These limitations become especially important when names are misspelled, addresses change, identifiers are missing, or patients receive care across multiple facilities. This article develops a conceptual model that combines probabilistic record linkage with machine learning to detect duplicate patient records. The model uses demographic similarity, address variation, encounter history, insurance identifiers, and clinical pattern matching as complementary evidence streams. The proposed model first applies probabilistic blocking to generate candidate record pairs, then uses a deep learning classifier, such as a Siamese network, to score pairs based on static and dynamic features. The output is a duplicate probability that can support automated ranking, human review, and master patient index maintenance. Conceptually, the model would be expected to improve duplicate detection compared with purely probabilistic linkage when demographic data are incomplete or unstable. Its main advantage is that it can anchor linkage decisions in more stable encounter patterns, longitudinal clinical trajectories, and repeated institutional contact signals. Such a hybrid model could enable a more accurate and self-maintaining master patient index while reducing the burden of manual record merging. It would also support safer registration workflows by identifying probable duplicates before identity fragmentation affects care delivery.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 25 February 2025 | Article: 103

Artificial Intelligence for Healthcare Quality Improvement from 2017 to 2024: A Systematic Review of Predictive Models for Safety Events, Care Gaps, Adverse Outcomes, and Performance Monitoring
Healthcare quality improvement increasingly relies on routinely collected data to identify preventable harm, missed care opportunities, adverse outcomes, and variation in performance. Artificial intelligence predictive models may support earlier detection of quality risks and enable more proactive monitoring than retrospective audits alone. This systematic review examined artificial intelligence predictive models for healthcare quality improvement from 2017 to 2024. The review focused on patient safety events, care gaps, adverse clinical outcomes, and performance monitoring systems. A PRISMA 2020-compliant search was conducted across PubMed, Scopus, Web of Science, and IEEE Xplore for peer-reviewed English-language studies published from 2017 through 2024. Dual screening, structured data extraction, risk-of-bias assessment, and narrative synthesis were used. The evidence base showed growing use of machine learning for pressure injuries, sepsis, readmission, mortality, ICU transfer, and continuous monitoring. However, most studies remained retrospective model-development or validation studies, while fewer described deployment within formal quality improvement workflows. Technical progress in predictive modelling for quality improvement is substantial, but evidence of sustained improvement in care processes, safety outcomes, or organisational performance remains limited. Stronger prospective evaluation and clearer integration with improvement methods are needed.
Journal of Health Informatics and Digital Systems
Review | Open access | 25 February 2025 | Article: 104

Machine Learning for Patient Transfer and Discharge Planning: A Review of Predictive Models for Placement Delay, Discharge Readiness, Follow-Up Completion, and Post-Discharge Risk
Hospital patient flow depends on timely transfer decisions, accurate discharge planning, and reliable post-discharge coordination. Delays in placement, premature discharge, missed follow-up, and unrecognized post-discharge risk can increase avoidable utilization and compromise continuity of care. This systematic review examined machine learning models for predicting placement delay, discharge readiness, follow-up completion, and post-discharge risk from 2017 to 2024. The objective was to synthesize model purposes, data sources, validation practices, implementation maturity, and practical relevance for care transitions. A PRISMA 2020-compliant systematic review was conducted using PubMed, Scopus, IEEE Xplore, and Web of Science. Dual screening, structured data extraction, and narrative synthesis were used because heterogeneity in model objectives, predictors, settings, and outcomes prevented meta-analysis. The evidence base was largest for post-discharge readmission risk and discharge readiness prediction, while placement delay and follow-up completion received less focused attention. Prospective validation, workflow integration, and outcome-based implementation studies were uncommon across all four domains. Machine learning offers promising tools to support proactive discharge planning and transitional care, but the evidence remains dominated by retrospective model development. Translation into routine practice requires prospective testing, interpretability, equity assessment, and integration into multidisciplinary workflows.
Journal of Health Informatics and Digital Systems
Review | Open access | 25 February 2025 | Article: 105

Artificial Intelligence for Healthcare Equity Analytics from 2017 to 2024: A Systematic Review of Bias Detection, Fairness-Aware Prediction, Disparity Monitoring, and Algorithmic Accountability in Health Systems
Artificial intelligence models are increasingly used to support healthcare decision-making, resource allocation, clinical triage, population health management, and quality improvement. Without explicit equity assessment, these tools may reproduce, obscure, or scale existing disparities across racial, ethnic, sex, gender, socioeconomic, and geographic groups. This systematic review examined artificial intelligence approaches for healthcare equity analytics from 2017 to 2024. The review focused on bias detection, fairness-aware prediction, disparity monitoring, and algorithmic accountability in health systems. A PRISMA 2020-compliant search was conducted across PubMed, Scopus, Web of Science, and IEEE Xplore for peer-reviewed English-language studies published between 2017 and 2024. Eligible records were screened by two reviewers, and findings were synthesised narratively by equity task, method type, clinical application, fairness metric, and implementation context. The evidence base showed increasing attention to bias detection and fairness-aware algorithm design, especially in clinical risk prediction, diagnostic imaging, and population health management. Disparity monitoring systems and accountability structures were less frequently evaluated in deployed health system environments and were commonly described as governance recommendations, audit frameworks, or pilot-stage approaches. The technical foundations for equitable artificial intelligence in healthcare are advancing, but translation into operational health system practice remains limited. The strongest evidence concerns bias measurement, whereas evidence that fairness interventions reduce real-world health disparities remains nascent.
Journal of Health Informatics and Digital Systems
Review | Open access | 25 February 2025 | Article: 106

Natural Language Processing for Healthcare Administration from 2017 to 2024: A Review of Models for Clinical Documentation, Coding Support, Incident Reporting, Patient Communication, and Workflow Automation
Healthcare administration generates large volumes of textual data, including clinical notes, billing documentation, incident narratives, portal messages, and operational records. These data create administrative burden but also provide opportunities for natural language processing to support documentation, coding, communication, safety review, and workflow automation. This systematic review examined natural language processing models applied to healthcare administration from 2017 to 2024. The review focused on five domains: clinical documentation, coding support, incident reporting, patient communication, and workflow automation. A PRISMA 2020-compliant review was conducted using structured searches of PubMed, Scopus, IEEE Xplore, and Web of Science for studies published between 2017 and 2024. Eligible studies were screened by two reviewers, extracted using a structured template, and synthesized narratively by administrative domain, model type, evaluation approach, and implementation maturity. Transformer-based models were increasingly prominent across the reviewed literature, particularly in documentation support, automated coding, and clinical text classification. Clinical documentation and coding support had the strongest evidence base, while incident reporting, patient communication, and workflow automation remained less mature and less frequently evaluated in real-world settings. Natural language processing for healthcare administration is technically promising, but most applications remain at the retrospective or proof-of-concept stage. Prospective validation, workflow integration, governance, and human oversight are needed before widespread operational adoption.
Journal of Health Informatics and Digital Systems
Review | Open access | 25 February 2025 | Article: 107

Retrieval-Augmented Clinical Operations Assistant for Answering Hospital Policy Questions Using Local Protocols, Staffing Guidelines, Bed Management Rules, Escalation Pathways, and Real-Time Operational Dashboards
Hospital staff routinely spend substantial cognitive effort locating operational policies, staffing rules, escalation pathways, and dashboard metrics across fragmented repositories. This hidden search burden can slow decision-making during high-pressure clinical operations. Current hospital knowledge environments rarely support natural-language policy questions answered from the institution’s own approved documents. Staff may know what they need to ask, but not where the relevant rule, protocol, or dashboard field is stored. This article proposes a retrieval-augmented clinical operations assistant that accepts free-text questions and retrieves relevant passages from local policy repositories and structured operational data sources. The assistant would synthesize a grounded response while exposing the sources used to generate the answer. The proposed assistant includes a document ingestion pipeline, a vector store, a permissioned large language model, a real-time dashboard connector, and a simple chat interface embedded in the hospital intranet. These components would work together to make local protocols, staffing guidelines, bed management rules, and escalation pathways conversationally accessible. The assistant would be expected to reduce staff search burden, improve visibility of current policy, and support more consistent use of institutional operating rules. Its value would depend on strict grounding in authoritative documents, robust version control, and clear boundaries when policies are missing or contradictory. A retrieval-augmented clinical operations assistant represents an early step toward conversational, trustworthy, and continually updated operational decision support. Such a system should complement, rather than replace, human judgment and formal policy governance.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 25 February 2025 | Article: 108

Deep Learning Model for Predicting Pharmacy Verification Backlogs Using Medication Order Complexity, Pharmacist Staffing, Patient Acuity, High-Alert Medication Flags, and Historical Queue Dynamics
Pharmacy verification is a critical safety checkpoint that protects patients from inappropriate medication use before administration. Verification backlogs can emerge when complex orders, high patient demand, and limited pharmacist capacity converge. Backlog management is often reactive because supervisors typically recognize risk only after the queue is already growing. By that point, turnaround times may already be delayed and urgent orders may compete with routine workload. This article proposes a conceptual deep learning model to forecast pharmacy verification backlog depth over short operational horizons. The model integrates medication order characteristics, pharmacist staffing, patient acuity, high-alert medication flags, and historical queue dynamics. The proposed model would use timestamped medication orders, staffing indicators, acuity signals, and queue-state variables as a multivariate temporal input stream. A recurrent or temporal convolutional neural network could transform these inputs into predicted queue length and backlog probability for upcoming time windows. Conceptually, the model would provide early warning of impending verification congestion before the queue becomes operationally disruptive. Such forecasts could support pre-emptive pharmacist reallocation, prioritization of urgent orders, and improved shift-lead situational awareness. A deep learning approach could shift pharmacy operations management from retrospective queue monitoring toward proactive backlog prevention. This model-oriented framework offers a foundation for future prospective evaluation in high-volume hospital pharmacy environments.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 20 July 2025 | Article: 109

Explainable Machine Learning Framework for Predicting Preventable Appointment Cancellations Using Scheduling Notes, Patient Communication History, Weather Conditions, Transportation Barriers, and Prior Attendance Behavior
Appointment cancellations undermine clinic efficiency, disrupt continuity of care, and reduce access for patients waiting for limited appointment slots. Many cancellations may be preventable when risk is recognized early enough for staff to intervene with reminders, rescheduling support, transportation assistance, or telemedicine conversion. Existing appointment-risk models often emphasize historical attendance and demographic information while underusing scheduling notes, patient communication history, weather conditions, and transportation barriers. They also frequently provide risk scores without patient-specific explanations that staff can translate into meaningful outreach. This article proposes an explainable machine learning framework for predicting preventable appointment cancellations before the appointment occurs. The framework is designed to identify not only which appointments may be at risk, but also why the cancellation risk is elevated. The proposed framework uses a gradient-boosted classification model trained on structured scheduling variables, prior attendance behavior, communication history, weather-linked features, transportation indicators, and natural language processing outputs from scheduling notes. SHAP-based explanation layers would decompose each prediction into interpretable drivers that can be reviewed by scheduling staff, clinic managers, and governance teams. Conceptually, the framework would output a cancellation risk score together with a natural-language explanation of the dominant drivers. These outputs could support targeted interventions such as reminder escalation, proactive rescheduling, transportation support, or conversion to a virtual visit when appropriate. An explainable framework for preventable appointment cancellation prediction could shift patient access management from reactive backfilling toward proactive retention. By combining heterogeneous access signals with transparent attribution, clinics could better align outreach resources with patient-specific barriers.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 20 July 2025 | Article: 110

Federated Analytics Framework for Benchmarking Hospital Operational Performance Across Health Systems Using Secure Aggregation of Bed Occupancy, Discharge Delays, Staffing Ratios, and Service Demand Indicators
Hospitals lack an objective and privacy-preserving mechanism to compare operational performance against peer institutions. This limits shared learning around capacity, discharge flow, staffing, and service demand. Traditional benchmarking often depends on centralized data warehouses, voluntary reporting, or retrospective surveys. These approaches can create privacy, competitive, regulatory, and selection-bias concerns that discourage full participation. This article proposes a federated analytics framework for computing aggregate operational benchmarks without moving raw hospital data outside local institutional boundaries. The framework would support medians, percentiles, and risk-adjusted comparative indicators through secure aggregation. The framework combines a local data standardization engine, a secure multi-party computation aggregator, a differential privacy injector, and a participatory dashboard. Together, these components would allow each hospital to compare its position against anonymous peer distributions. The framework could enable hospitals to identify performance gaps in bed occupancy, discharge delays, staffing ratios, and service demand while preserving confidentiality. It would be expected to encourage more honest participation because institutional data sovereignty remains intact. A federated analytics approach offers a practical pathway for collaborative operations improvement across health systems. It aligns benchmarking, privacy protection, and organizational learning within a single governance-aware framework.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 20 July 2025 | Article: 111

Predictive Model for Forecasting Diagnostic Service Demand Using Ambulatory Referral Volume, Seasonal Disease Trends, Physician Ordering Patterns, Equipment Availability, and Historical Appointment Backlogs
Diagnostic services are central to clinical decision-making because imaging, laboratory testing, and cardiology diagnostics often determine the next step in diagnosis, treatment, or referral. Bottlenecks in these services can delay care pathways and increase wait times when demand rises faster than available capacity. Current forecasting approaches in diagnostic departments are often reactive and based on historical averages, recent appointment counts, or manual manager judgment. Such approaches may miss upstream signals such as referral surges, seasonal disease activity, and physician ordering behavior. This article proposes a predictive model for forecasting diagnostic service demand by integrating ambulatory referral volume, seasonal disease trends, physician ordering patterns, equipment availability, and historical appointment backlogs. The model is intended to support short- and medium-term capacity planning across diagnostic services. The proposed approach uses a supervised time-series forecasting framework, such as gradient boosting with temporal features or a recurrent neural architecture, trained on historical diagnostic order and scheduling data. Inputs would be engineered from referral streams, diagnostic ordering records, seasonal indicators, equipment schedules, and backlog measures. Conceptually, the model would generate daily or weekly demand forecasts for each diagnostic modality and service line. Forecasts would include uncertainty bounds and operational alerts when projected demand is expected to exceed available appointment capacity. The proposed predictive model could enable proactive capacity management in diagnostic departments. By anticipating demand before backlogs become severe, the model could support improved scheduling, better equipment utilization, and reduced patient waiting times.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 20 July 2025 | Article: 112

Large Language Model for Generating Patient-Friendly Care Navigation Instructions from Referral Orders, Clinic Requirements, Insurance Rules, Preparation Instructions, and Scheduling Constraints
Navigating specialty care often requires patients to understand referral reasons, appointment logistics, preparation rules, insurance requirements, and follow-up expectations. These instructions are frequently distributed across separate documents and portals, creating avoidable confusion for patients and caregivers. No unified system currently converts fragmented referral, clinic, insurance, preparation, and scheduling information into one personalized, plain-language care navigation guide. As a result, patients may miss critical steps before appointments or misunderstand what they need to do. This article proposes a conceptual large language model system for generating patient-friendly care navigation instructions from clinical, administrative, and scheduling data. The objective is to describe how such a system could support clearer, safer, and more accessible patient communication. The proposed pipeline would extract relevant facts from referral orders, clinic requirements, insurance rules, preparation instructions, and scheduling constraints. A retrieval-augmented LLM would then synthesize these facts into a cohesive instruction sheet with traceability back to verified institutional sources. Conceptually, the system would generate a clear, step-by-step appointment guide tailored to the patient’s language, health literacy needs, and preferred communication channel. The output would be expected to reduce cognitive burden by consolidating complex healthcare logistics into one practical message. An LLM-based patient navigation instruction system could bridge the communication gap between healthcare operations and patient understanding. Responsible deployment would require strong grounding, validation, accessibility design, and human oversight for high-risk instructions.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 20 July 2025 | Article: 113

Graph Neural Network for Predicting Fragmented Care Episodes Using Provider Networks, Encounter Sequences, Referral Patterns, Cross-Setting Utilization, and Unresolved Care Gap Indicators
Care fragmentation is a silent driver of adverse outcomes because it distributes responsibility for a patient’s care across multiple providers, settings, and transitions. It is often recognized only after duplication, missed follow-up, or contradictory management has already occurred. Fragmentation unfolds through networks of providers, referrals, encounters, and unresolved care tasks. Conventional prediction models often treat these events as independent patient-level variables rather than as relational patterns embedded in a care system. This article develops a conceptual graph neural network model for predicting the likelihood of fragmented care episodes. The proposed model uses provider networks, encounter sequences, referral patterns, cross-setting utilization, and unresolved care gap indicators as an integrated graph representation. A heterogeneous graph is constructed with patient and provider nodes, while edges represent encounters, referrals, shared patients, cross-setting transitions, and unresolved care gaps. A graph neural network learns patient embeddings from this relational structure and produces a fragmentation risk score for each patient-period. Conceptually, the model would identify patients at elevated risk of fragmentation, such as those moving across many disconnected providers, receiving repeated referrals, or accumulating open follow-up tasks. These signals could support earlier care coordination before avoidable gaps widen into adverse outcomes. The relational lens of graph neural networks could transform fragmentation prediction from a static risk scoring task into a network-aware early-warning system. Such a model would be expected to help health systems detect fragmented care episodes before they become operationally and clinically consequential.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 20 July 2025 | Article: 114

Interpretable Machine Learning Model for Predicting Prior Authorization Approval Delays Using Payer-Specific Rules, Clinical Documentation Features, Procedure Type, Medical Necessity Indicators, and Historical Approval Timelines
Prior authorization delays impede timely patient care and contribute to administrative pressure across clinical and revenue cycle workflows. These delays can affect scheduling, medication access, procedural planning, and patient confidence in the care process. Current authorization management tools are largely reactive and often focus on tracking request status after submission. They rarely predict which requests are likely to experience approval delays or explain the operational, clinical, or payer-specific reasons behind those delays. This article proposes an interpretable machine learning model for predicting the likelihood of prior authorization approval delays. The model is designed to provide transparent, request-level explanations that can guide pre-submission correction and authorization preparation. The proposed framework uses a gradient-boosted tree model trained conceptually on historical authorization requests. Inputs include payer-specific rules, clinical documentation features, procedure type, medical necessity indicators, and historical approval timelines, with SHAP used to attribute predicted delay risk to individual features. Conceptually, the model would output a delay probability and an explanation of the dominant drivers of that prediction. These drivers could include incomplete documentation, mismatch with payer medical necessity criteria, procedure categories associated with additional review, or payer-procedure combinations with historically slow turnaround. An interpretable prior authorization delay model could support earlier correction of incomplete requests, reduce administrative waste, and improve patient access. By aligning predictive analytics with transparent explanations, the framework could make authorization preparation more proactive and accountable.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 20 July 2025 | Article: 115

Machine Learning Model for Forecasting Hospital Housekeeping Demand Using Discharge Predictions, Room Turnover History, Isolation Status, Environmental Cleaning Requirements, and Unit-Level Census Patterns
Hospital housekeeping demand is closely tied to bed turnover, discharge timing, isolation precautions, and unit-level patient movement. Delays in environmental services completion can slow bed availability and create downstream pressure on emergency departments, inpatient units, and procedural areas. Environmental services staffing is often managed through fixed shift patterns, current occupancy views, and reactive dispatch queues. These approaches may not anticipate cleaning surges caused by clustered discharges, isolation rooms, or changing census patterns. This manuscript proposes a predictive model for forecasting hospital housekeeping demand by combining discharge predictions, room turnover history, isolation status, environmental cleaning requirements, and unit-level census signals. The goal is to estimate the number, type, and timing of cleaning tasks needed across hospital units. The proposed model would use historical environmental services logs, admission-discharge-transfer data, bed management data, discharge prediction outputs, and infection-control status indicators. A supervised regression or time-series architecture could generate hourly unit-level demand forecasts for routine, terminal, and enhanced cleaning tasks. Conceptually, the model would be expected to identify upcoming cleaning pressure before it appears on the live dispatch board. For example, it could anticipate an afternoon surge in terminal cleans when several predicted discharges coincide with isolation rooms and high unit census. A forecasting model for housekeeping demand could support proactive environmental services staffing, reduce avoidable bed turnaround delays, and improve hospital throughput. Its value would depend on careful integration with existing bed management systems and prospective evaluation in operational settings.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 20 July 2025 | Article: 117

Artificial Intelligence System for Detecting Preventive Care Delivery Gaps Using Primary Care Records, Screening Eligibility Rules, Reminder Logs, Patient Portal Activity, and Visit Opportunity Windows
Preventive care delivery remains inconsistent despite well-established recommendations for cancer screening, immunization, and chronic disease monitoring. Missed preventive services create avoidable downstream morbidity, delayed diagnosis, and inefficient use of primary care resources. Current preventive care gap closure strategies are often reactive, fragmented, and dependent on manual review. Primary care clinicians cannot feasibly reconstruct every patient’s eligibility status, prior reminders, portal behavior, and visit timing during brief encounters. This article proposes an artificial intelligence system that continuously analyzes primary care records, applies screening eligibility rules, integrates reminder logs and patient portal activity, and detects upcoming visit opportunity windows. The system would surface a personalized preventive care gap list before or during clinical contact. The framework includes a rules engine for guideline-based eligibility, an engagement module that interprets reminder history and portal behavior, a visit opportunity detector, and a prioritization engine. Together, these components would rank preventive actions by clinical relevance, timing feasibility, and patient readiness. The system would transform routine primary care encounters into targeted preventive care opportunities by delivering the right recommendation at the right moment. By combining eligibility logic with engagement and visit context, it could support proactive care without relying solely on clinician memory. A proactive, AI-enhanced preventive care system could narrow the gap between evidence-based recommendations and real-world delivery. Its value would depend on transparent rule design, workflow-sensitive implementation, and careful prospective evaluation.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 20 July 2025 | Article: 118

Conversational Artificial Intelligence Assistant for Generating Structured Quality Improvement Reports from Incident Narratives, Safety Event Classifications, Root-Cause Analysis Notes, and Performance Metrics
Quality improvement reports distill incident narratives, safety classifications, root-cause analyses, and performance metrics into actionable learning documents. However, compiling these materials remains a manual, cognitively burdensome task that can delay organizational learning after safety events. Healthcare organizations often hold rich safety data across reporting systems, RCA documents, dashboards, and governance records. Yet these inputs are rarely transformed into standardized QI reports through a single coherent workflow. This article proposes a conversational artificial intelligence assistant that engages quality officers in a structured dialogue, retrieves relevant safety-event evidence, and generates a draft QI report following a pre-specified template. The assistant is conceptualized as a human-supervised system rather than an autonomous decision-maker. The proposed assistant includes an incident narrative NLP module, safety classification aligner, RCA note retriever, performance metric trend summarizer, and template-guided large language model. These components would support structured reporting while preserving human review and organizational accountability. The assistant could shorten the time from incident review to report drafting, improve reproducibility across QI documentation, and reduce administrative burden for patient safety teams. Its value would depend on careful grounding, privacy protection, verification workflows, and user trust. Conversational AI offers a pathway toward AI-augmented safety reporting that supports, rather than replaces, human expertise. The proposed model emphasizes structured synthesis, transparent evidence use, and a learning culture in healthcare quality improvement.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 25 February 2025 | Article: 143
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AI-driven Diagnostics Artificial Intelligence in Health Informatics Artificial Intelligence in Healthcare Big Data in Healthcare Clinical Data Mining Clinical Decision Support Systems Clinical Informatics Computer Vision Connected Health Systems Deep Learning Digital Health Digital Healthcare Innovation Digital Transformation in Healthcare Electronic Health Records Ethical AI in Healthcare Explainable AI Health Data Analytics Health Data Privacy Health Informatics Health Information Management Health Information Systems Health System Optimization Health Technology Assessment Healthcare Data Science Healthcare Informatics Healthcare Information Security Healthcare Management Healthcare Management Information Systems Intelligent Medical Systems Internet of Medical Things (IoMT) Interoperability in Healthcare Systems Machine Learning Medical Data Analytics Medical Data Management Medical Imaging Mobile Health (mHealth) Natural Language Processing Precision Medicine Predictive Analytics Remote Patient Monitoring Smart Healthcare Systems Telemedicine Wearable Health Technologies e-Health




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