Articles

Large Language Models in Clinical Medicine from 2017 to 2025: A Systematic Review of Performance on Medical Licensing Examinations, Clinical Documentation, Decision Support, and Safety Concerns

Gabriel Costa, Rafael Mendes, Bruno Teixeira & Lucas Ribeiro

Review | Open access | 20 January 2026 | Article: 121

Deep Learning for Oncology Drug Discovery: A Systematic Review of Target Identification, Compound Screening, and Clinical Trial Optimization

Sophie Laurent, Pierre Dubois, Marc Lefevre & Claire Moreau

Review | Open access | 20 January 2026 | Article: 122

Machine Learning for Predicting Sepsis in Hospitalized Patients: A Systematic Review of Model Types, Feature Engineering Approaches, Prediction Horizons, and Prospective Validation Studies

Ahmed Al-Sayed & Omar Khalid

Review | Open access | 20 January 2026 | Article: 123

Generative Artificial Intelligence for Synthetic Electronic Health Record Data Generation: A Critical Review of Methods, Privacy Risks, Fidelity Metrics, and Downstream Task Utility

Victor Hugo, Daniel Cruz & Javier Salazar

Review | Open access | 20 January 2026 | Article: 124

Artificial Intelligence for Sleep Medicine and Sleep Disorder Diagnosis: A Systematic Review of Deep Learning Models for Polysomnography, Home Sleep Apnea Testing, and Wearable Device Analysis

Elif Yilmaz, Mehmet Demir, Ayse Kaya & Hasan Aydin

Review | Open access | 20 January 2026 | Article: 125

Federated Learning for Rare Disease Diagnosis and Research: A Systematic Review of Methods for Handling Extreme Data Scarcity, Class Imbalance, and Site Heterogeneity

Luca Bianchi, Marco Rossi & Giulia Romano

Review | Open access | 20 January 2026 | Article: 126

Toward Scalable Federated Oncology Screening: A Multi-Layer Intelligence Architecture for Early Cancer Detection

Ali Hassan, Noor Siddiqui, Bilal Khan & Sana Malik

Original Research | Open access | 20 July 2025 | Article: 39

A Synthetic Health Data Governance Framework for Generative AI–Enabled Clinical Ecosystems

Chen Hao, Liu Fang & Zhao Lin

Original Research | Open access | 20 July 2025 | Article: 40

Large Language Models in Clinical Contexts: Infrastructure, Oversight, and Risk Dynamics

Andreas Müller, Stefan Weber, Julia Hoffmann, Lukas Schneider & Tobias Klein

Review | Open access | 20 July 2025 | Article: 41

Generative Artificial Intelligence in Healthcare: Systems Governance, Safety, and Accountability

Maria Silva & Joao Pereira

Review | Open access | 20 July 2025 | Article: 42

AI Governance in Healthcare: Transparency, Bias Mitigation, and Lifecycle Monitoring Models

Ahmed Benali, Yasmine Cherif, Karim Boudiaf & Samir Touati

Review | Open access | 20 July 2025 | Article: 43

Federated Reinforcement Learning for Coordinated Bed Allocation and Nurse Staffing During Pandemic Surges

Lucia Morales, Diego Perez, Valeria Soto, Martin Alvarez & Fernando Diaz

Original Research | Open access | 20 July 2025 | Article: 104

A Contrastive Multi-View Learning Framework for Long COVID Phenotype Discovery from Electronic Health Records

Patrick O’Connor & Sean Murphy

Original Research | Open access | 20 July 2025 | Article: 105

A Diffusion-Based Generative Framework for Synthetic Arrhythmia ECG Signals

Nguyen Van Nam, Tran Thi Hoa & Le Minh Duc

Original Research | Open access | 20 July 2025 | Article: 106

A Dynamic Graph Neural Network Framework for Chronic Postsurgical Pain Trajectory Prediction Using Temporal Opioid and Psychological Data

Samuel Boateng, Kwesi Mensah, Kojo Asante & Linda Owusu

Original Research | Open access | 20 July 2025 | Article: 107

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