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An AI-Orchestrated Emergency Department Triage Intelligence Architecture
The rapid influx of patients in emergency departments (EDs) necessitates advanced systems for triage prioritization, where artificial intelligence (AI) can orchestrate decision-making to enhance efficiency and equity. This conceptual manuscript proposes a novel AI-orchestrated triage intelligence architecture designed to integrate heterogeneous data streams, clinical workflows, and governance mechanisms within ED settings. Drawing from peer-reviewed literature on clinical AI architectures, healthcare analytics infrastructures, and decision support pipelines, we synthesize theoretical foundations to outline a layered orchestration topology that addresses interoperability challenges, real-time intelligence processing, and ethical monitoring. The proposed framework, termed the emergency triage orchestration lattice (ETOL), features modular layers for data ingestion, predictive analytics, orchestration governance, and feedback integration, ensuring adaptive triage without empirical validation. Conceptual formulas capture decision confidence aggregation and governance load distribution, highlighting theoretical trade-offs in latency and resource allocation. By emphasizing infrastructural resilience and human-AI symbiosis, this architecture theorizes improved triage throughput and reduced bias propagation in high-acuity environments. Implications for ED workflow redesign and AI deployment scalability are discussed, underscoring the need for robust interoperability frameworks to support future intelligence ecosystems. This work contributes to the discourse on AI governance in acute care, advocating for orchestrated systems that prioritize clinical relevance over isolated algorithmic performance.
Journal of Artificial Intelligence for Healthcare Systems
Original Research | Open access | 20 July 2023 | Article: 14

Predictive Analytics for Emergency Department Crowding and Patient Flow Optimization: A Systematic Review of Machine Learning Models, Input Features, and Operational Outcomes
Emergency department crowding is a persistent global healthcare challenge linked to longer wait times, increased patients leaving without being seen, worse clinical outcomes, and staff burnout. It also contributes to ambulance diversion and inefficient resource use, worsening hospital operational strain. This systematic review evaluates machine learning models for predicting ED crowding and optimizing patient flow, focusing on input features (e.g., arrival rates, acuity, bed availability) and reported operational outcomes such as waiting times and ambulance delays. A PRISMA-compliant review was conducted across PubMed, Embase, IEEE Xplore, and Scopus. Included studies applied machine learning to ED crowding or patient flow prediction and reported operational or crowding outcomes. Due to heterogeneity, a narrative synthesis was used, and risk of bias was assessed using an adapted tool. Thirty-two studies met inclusion criteria, using classification, regression, time-series, and deep learning models. Common predictors included arrival patterns, occupancy, and bed availability. While predictive performance was generally high, few studies evaluated real-world operational impacts, and most remained retrospective. Although machine learning models demonstrate strong predictive accuracy for ED crowding, evidence of real-world operational benefits remains limited. A clear gap exists between prediction and implementation into clinical workflow and decision-making. Future research should focus on translating predictions into measurable improvements in ED performance.
Journal of Artificial Intelligence for Healthcare Systems
Review | Open access | 20 January 2023 | Article: 68

Large Language Model with Retrieval-Augmented Generation and Chain-of-Thought Reasoning for Differential Diagnosis Generation from Emergency Department Triage Notes and Vital Signs
This article proposes a conceptual framework for a diagnostic support system in emergency departments that leverages large language models, retrieval-augmented generation, and chain-of-thought reasoning. By combining triage notes and vital signs, the system generates a ranked differential diagnosis list to assist clinicians without replacing their judgment. The framework includes components like a triage note encoder, a vital sign encoder, a retrieval module, and a diagnosis ranker, using evidence from clinical guidelines, curated references, and de-identified prior cases. The approach grounds the model in authoritative knowledge while ensuring transparency and explainability in the diagnostic process. However, prospective validation, integration into workflows, and clinician oversight are crucial before implementation to ensure safety and effectiveness.
Journal of Artificial Intelligence for Healthcare Systems
Original Research | Open access | 20 July 2026 | Article: 129

Contrastive Learning with Prototypical Networks for Few-Shot Detection of Emerging Infectious Disease Outbreaks from Emergency Department Chief Complaints and Triage Notes
Emergency department chief complaints and triage notes are early indicators of health changes during infectious disease outbreaks. These records, made before confirmatory testing, provide a presyndromic view of population health. Traditional syndromic surveillance relies on predefined syndrome categories, which may not align with novel pathogens. Early outbreaks often present as sparse, ambiguous symptom clusters, resulting in few labeled examples for automated detection. This framework suggests using contrastive learning with prototypical networks for few-shot detection of emerging infectious disease syndromes from free-text notes. It leverages historical data to create a robust clinical text embedding space, with a small set of labeled examples defining new syndromes. The system includes a contrastive pre-training encoder, prototypical network, and few-shot classifier. The encoder learns from unlabelled historical notes, and the prototypical network creates syndrome prototypes from a few labeled examples. This framework is designed for situations where public health officials observe early suspect cases but lack mature labeled datasets. It can identify early clusters by comparing incoming notes to emerging syndrome prototypes. Contrastive learning with prototypical networks enables proactive presyndromic surveillance, allowing rapid adaptation during the early phase of an outbreak without relying on large labeled datasets.
Journal of Artificial Intelligence for Healthcare Systems
Original Research | Open access | 20 July 2026 | Article: 133

Explainable Gradient Boosting Framework for Identifying Key Drivers of Delayed Emergency Department Discharge Using Diagnostic Order Completion Times, Bed Availability, Consultant Response Delays, and Patient Acuity Scores
Emergency department discharge delays are a critical operational bottleneck shaped by diagnostic completion intervals, inpatient bed scarcity, consultant responsiveness, and patient acuity. Understanding these drivers in real time is essential for improving flow and reducing avoidable crowding. Current ED analytics often describe aggregate delays after they occur. Clinicians and operational managers therefore lack transparent patient-level tools that indicate which factor is most responsible for a specific delayed discharge episode. This article proposes an explainable gradient-boosting framework for identifying key contributors to delayed ED discharge. The framework focuses on diagnostic order completion times, bed availability, consultant response delays, and patient acuity scores. The proposed framework uses a gradient-boosted tree ensemble trained on historical ED visit data and paired with SHAP-based post-hoc explanations. It is designed conceptually for real-time use with live electronic health record, bed-board, order, and consultation data. Conceptually, the framework would generate both a delay-risk score and an interpretable decomposition of that risk. These explanations could support targeted actions such as expediting a pending diagnostic test, escalating bed-management review, or re-contacting a delayed consultant service. The framework would shift ED discharge management from reactive reporting toward proactive operational decision support. Explainability is positioned as the foundation for clinician trust, workflow alignment, and accountable deployment.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 25 February 2022 | Article: 67

Transparent Machine Learning Model for Predicting Delayed Follow-Up After Emergency Department Visits Using Discharge Instructions, Appointment Availability, Portal Engagement, Social Risk Data, and Visit Severity
Many patients discharged from emergency departments require timely outpatient follow-up to complete diagnostic, therapeutic, or monitoring plans. When follow-up is delayed, unresolved symptoms, missed diagnoses, medication problems, and preventable return visits may occur. Current discharge workflows often rely on generic instructions and assume that patients can understand, schedule, and attend recommended care. Existing prediction approaches do not consistently combine unstructured discharge instructions, appointment access, portal engagement, social risk, and visit severity in a transparent way.This article proposes a transparent machine learning framework for predicting delayed follow-up after emergency department visits. The objective is to support patient-specific discharge planning by identifying both the likelihood of delay and the most actionable contributing barriers. The proposed model would combine structured emergency department and scheduling data with natural language processing features extracted from discharge instructions. A gradient-boosted tree model with SHAP-based explanations would provide patient-level and population-level interpretability. Conceptually, the model would identify patients at elevated risk of delayed follow-up and attribute that risk to factors such as unclear instructions, limited appointment availability, absent portal engagement, transportation barriers, or higher visit complexity. These explanations would be intended to guide targeted interventions rather than replace clinical judgment. A transparent model for delayed follow-up prediction could enable precision transitional care after emergency department discharge. By aligning predictions with actionable explanations, care teams could direct limited resources toward the specific barrier most likely to prevent timely follow-up.
Journal of Health Informatics and Digital Systems
Original Research | Open access | 20 July 2026 | Article: 133
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AI-driven Diagnostics Artificial Intelligence in Health Informatics Artificial Intelligence in Healthcare Big Data in Healthcare Clinical Data Mining Clinical Decision Support Systems Clinical Informatics Computer Vision Connected Health Systems Deep Learning Digital Health Digital Healthcare Innovation Digital Transformation in Healthcare Electronic Health Records Ethical AI in Healthcare Explainable AI Health Data Analytics Health Data Privacy Health Informatics Health Information Management Health Information Systems Health System Optimization Health Technology Assessment Healthcare Data Science Healthcare Informatics Healthcare Information Security Healthcare Management Healthcare Management Information Systems Intelligent Medical Systems Internet of Medical Things (IoMT) Interoperability in Healthcare Systems Machine Learning Medical Data Analytics Medical Data Management Medical Imaging Mobile Health (mHealth) Natural Language Processing Precision Medicine Predictive Analytics Remote Patient Monitoring Smart Healthcare Systems Telemedicine Wearable Health Technologies e-Health




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