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Claim denials represent a major source of lost or delayed healthcare revenue. They are commonly driven by documentation gaps, coding inconsistencies, payer rule violations, and missing or invalid prior authorizations. Current denial prevention often depends on manual review and deterministic claim-scrubbing rules. These approaches may not capture complex payer-specific interactions among documentation quality, procedure codes, diagnosis codes, and authorization history. This article proposes an explainable gradient boosting model for estimating the probability that a health insurance claim could be denied before submission. The model is intended to identify the specific claim-level factors contributing to denial risk. The proposed framework uses a gradient-boosted tree ensemble trained conceptually on historical claims and remittance data. SHAP-based explanations would provide both global and local interpretability for denial-risk predictions. Conceptually, the model would return a denial risk score alongside an explanation of contributing factors such as incomplete documentation, diagnosis-code mismatch, expired authorization, or payer rule conflict. These outputs would support targeted pre-billing review rather than broad manual auditing. An explainable denial prediction model could help shift revenue cycle management from reactive appeals toward proactive prevention. Transparent reasoning would be essential for revenue cycle staff, clinical documentation teams, coders, and compliance stakeholders.

Revenue cycle inefficiencies, including claim denials, coding errors, delayed reimbursement, and prior authorization workload, impose substantial administrative and financial burdens on healthcare organizations. Machine learning has been proposed as a decision-support approach for improving prediction, automation, and workflow prioritization in these areas. This systematic review examined peer-reviewed and closely related scholarly literature from 2017 to 2023 on machine learning for healthcare revenue cycle analytics. The review focused on claim denial prediction, coding automation, payment delay forecasting, and prior authorization support. A PRISMA 2020-compliant review process was used, including structured database searching, dual screening, and domain-based narrative synthesis. Risk of bias was assessed using criteria adapted from PROBAST-AI, with attention to temporal validation, data leakage, and implementation relevance. The literature showed the greatest maturity in automated clinical coding and emerging but narrower evidence for claim denial prediction. Evidence for payment delay forecasting and prior authorization support was more limited, with few studies describing prospective implementation or measured operational impact. Machine learning shows promise for improving revenue cycle decision support, but most evidence remains retrospective and technically oriented. Deployment is constrained by data fragmentation, explainability requirements, workflow integration, and regulatory caution.