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Federated Transfer Learning Framework for Adapting COVID-19 Prognostic Models from High-Resource to Low-Resource Hospitals Using Only Aggregate Statistics
During the COVID-19 pandemic, machine learning models developed in high-resource hospitals achieved strong performance in predicting outcomes such as mortality, ICU admission, and mechanical ventilation, but their accuracy often degrades when applied to low-resource settings due to differences in patient populations, disease severity, clinical practices, and documentation quality. Low-resource hospitals also face limited patient volumes, incomplete labeled data, and strict privacy regulations (e.g., HIPAA and GDPR), which prevent centralized data sharing and hinder independent model development, creating a barrier to equitable AI deployment. To address this, we propose a federated transfer learning framework that adapts prognostic models from high-resource to low-resource hospitals without exchanging patient-level data. The approach transfers only aggregate statistics (e.g., feature means, variances, class-conditional distributions, and correlations) via a secure lightweight protocol, enabling target hospitals to align feature distributions using domain adaptation techniques and fine-tune models on small local datasets. The framework includes source model training, statistical aggregation, secure transmission, and target-side adaptation modules, ensuring no raw patient data leaves any institution. By relying on aggregate statistics, the method preserves privacy while mitigating domain shift and maintaining clinical utility across diverse healthcare environments. This scalable and privacy-preserving framework supports broader deployment of COVID-19 predictive models and provides a generalizable strategy for other medical conditions with heterogeneous healthcare settings.
Journal of Artificial Intelligence for Healthcare Systems
Original Research | Open access | 20 January 2026 | Article: 118
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AI-driven Diagnostics Artificial Intelligence in Health Informatics Artificial Intelligence in Healthcare Big Data in Healthcare Clinical Data Mining Clinical Decision Support Systems Clinical Informatics Computer Vision Connected Health Systems Deep Learning Digital Health Digital Healthcare Innovation Digital Transformation in Healthcare Electronic Health Records Ethical AI in Healthcare Explainable AI Health Data Analytics Health Data Privacy Health Informatics Health Information Management Health Information Systems Health System Optimization Health Technology Assessment Healthcare Data Science Healthcare Informatics Healthcare Information Security Healthcare Management Healthcare Management Information Systems Intelligent Medical Systems Internet of Medical Things (IoMT) Interoperability in Healthcare Systems Machine Learning Medical Data Analytics Medical Data Management Medical Imaging Mobile Health (mHealth) Natural Language Processing Precision Medicine Predictive Analytics Remote Patient Monitoring Smart Healthcare Systems Telemedicine Wearable Health Technologies e-Health




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