Search

Pancreatic cancer is highly lethal, and surgical resection is the only curative option. Preoperative assessment using contrast-enhanced CT is essential for determining tumor resectability based on involvement of key vessels such as the superior mesenteric artery, celiac trunk, and portal vein. Accurate pancreatic tumor segmentation is difficult due to unclear boundaries, low contrast with surrounding tissue, and proximity to major vessels. Manual segmentation is slow, subjective, and inconsistent, especially in borderline cases, while tumor-associated fibrosis further obscures lesion margins. We propose a deep learning-based framework using an attention-enhanced U-Net with multi-scale feature fusion and deep supervision for tumor segmentation and resectability assessment. The model incorporates attention gates, atrous spatial pyramid pooling, and auxiliary losses at multiple decoder levels to improve feature learning and gradient flow. A pre-trained encoder extracts hierarchical features refined by attention mechanisms in skip connections. A multi-scale decoder reconstructs segmentation maps, supported by deep supervision at different resolutions. A parallel branch models tumor–vessel spatial relationships using distance maps to improve resectability classification. This framework enables automated pancreatic tumor segmentation and resectability evaluation from CT scans, improving accuracy, interpretability, and clinical utility. Validation on datasets such as Pancreas-CT and Medical Segmentation Decathlon is recommended.

High-risk transitions of care remain a major source of preventable readmissions, emergency department use, medication harm, and post-discharge deterioration. Existing risk tools often simplify the transition period into structured clinical variables and may not fully represent clinical complexity, social vulnerability, medication safety, or home support. Discharge planning commonly depends on generic risk scores, clinician judgment, and incomplete structured fields. These approaches may overlook risk signals embedded in discharge summaries, medication reconciliation records, follow-up plans, case management documentation, and social risk screening. This manuscript proposes a conceptual deep learning model for predicting high-risk transitions of care. The model is designed to fuse discharge summary narratives, medication reconciliation data, follow-up appointment status, home support indicators, and social risk variables into a unified transition risk score. The proposed architecture combines a clinical language encoder for discharge summaries with a structured-data network for medication, follow-up, home support, and social risk features. These representations are integrated through a multimodal fusion layer that would generate a patient-level risk estimate at the point of discharge. Conceptually, the model could identify patients at elevated risk of readmission, emergency department use, or adverse post-discharge outcomes who might be missed by traditional scores. It would also be expected to highlight clinically interpretable risk drivers that could support targeted transitional care planning. A multimodal deep learning model could strengthen precision transitional care by integrating clinical, logistical, medication-related, and social dimensions of risk. Such a model could help discharge teams prioritize intensified interventions for patients most vulnerable to unsafe care transitions.

Pharmacy verification is a critical safety checkpoint that protects patients from inappropriate medication use before administration. Verification backlogs can emerge when complex orders, high patient demand, and limited pharmacist capacity converge. Backlog management is often reactive because supervisors typically recognize risk only after the queue is already growing. By that point, turnaround times may already be delayed and urgent orders may compete with routine workload. This article proposes a conceptual deep learning model to forecast pharmacy verification backlog depth over short operational horizons. The model integrates medication order characteristics, pharmacist staffing, patient acuity, high-alert medication flags, and historical queue dynamics. The proposed model would use timestamped medication orders, staffing indicators, acuity signals, and queue-state variables as a multivariate temporal input stream. A recurrent or temporal convolutional neural network could transform these inputs into predicted queue length and backlog probability for upcoming time windows. Conceptually, the model would provide early warning of impending verification congestion before the queue becomes operationally disruptive. Such forecasts could support pre-emptive pharmacist reallocation, prioritization of urgent orders, and improved shift-lead situational awareness. A deep learning approach could shift pharmacy operations management from retrospective queue monitoring toward proactive backlog prevention. This model-oriented framework offers a foundation for future prospective evaluation in high-volume hospital pharmacy environments.