cirpublications.com-JiTD-1790880686-j827489866 1790880686 Clinical Intelligence Research Press info@cirpublications.com Clinical Intelligence Research Press Journal of Health Informatics and Digital Systems J. Health Inform. Digit. Syst. 3149-8973 2026 6 1 Andrei Popescu Mihai Ionescu Elena Stan Sorin Dumitrescu Irina Pavel 2026 10.68159/j827489866 https://cirpublications.com/pub/journal/2/article/j827489866 Korngiebel DM, Mooney SD. Considering the possibilities and pitfalls of Generative Pre-trained Transformer 3 (GPT-3) in healthcare delivery. NPJ Digit Med. 2021;4(1):93. Harrer S. Attention is not all you need: the complicated case of ethically using large language models in healthcare and medicine. EBioMedicine. 2023;90:104512. Singhal K, Azizi S, Tu T, Mahdavi SS, Wei J, Chung HW, et al. Large language models encode clinical knowledge. Nature. 2023;620(7972):172-80. Thirunavukarasu AJ, Ting DSJ, Elangovan K, Gutierrez L, Tan TF, Ting DSW. Large language models in medicine. Nat Med. 2023;29(8):1930-40. Yang X, Chen A, PourNejatian N, Shin HC, Smith KE, Parisien C, et al. A large language model for electronic health records. NPJ Digit Med. 2022;5(1):194. Ayers JW, Poliak A, Dredze M, Leas EC, Zhu Z, Kelley JB, et al. Comparing physician and artificial intelligence chatbot responses to patient questions posted to a public social media forum. JAMA Intern Med. 2023;183(6):589-96. Van Veen D, Van Uden C, Blankemeier L, Delbrouck JB, Aali A, Bluethgen C, et al. Adapted large language models can outperform medical experts in clinical text summarization. Nat Med. 2024;30(4):1134-42. Liu S, McCoy AB, Wright AP, Carew B, Genkins JZ, Huang SS, et al. Leveraging large language models for generating responses to patient messages—a subjective analysis. J Am Med Inform Assoc. 2024;31(6):1367-79. Tang L, Sun Z, Idnay B, Nestor JG, Soroush A, Elias PA, et al. Evaluating large language models on medical evidence summarization. NPJ Digit Med. 2023;6(1):158. Clusmann J, Kolbinger FR, Muti HS, Carrero ZI, Eckardt JN, Laleh NG, et al. The future landscape of large language models in medicine. Commun Med (Lond). 2023;3(1):141. Moulaei K, Yadegari A, Baharestani M, Farzanbakhsh S, Sabet B, Afrash MR. Generative artificial intelligence in healthcare: a scoping review on benefits, challenges and applications. Int J Med Inform. 2024;188:105474. Pham JH, Thongprayoon C, Miao J, Suppadungsuk S, Koirala P, Craici IM, et al. Large language model triaging of simulated nephrology patient inbox messages. Front Artif Intell. 2024;7:1452469. Liu S, Wright AP, McCoy AB, Huang SS, Steitz B, Wright A. Detecting emergencies in patient portal messages using large language models and knowledge graph-based retrieval-augmented generation. J Am Med Inform Assoc. 2025;32(6):1032-9. Gaber F, Shaik M, Allega F, Bilecz AJ, Busch F, Goon K, et al. Evaluating large language model workflows in clinical decision support for triage and referral and diagnosis. NPJ Digit Med. 2025;8(1):263. Omiye JA, Gui H, Rezaei SJ, Zou J, Daneshjou R. Large language models in medicine: the potentials and pitfalls: a narrative review. Ann Intern Med. 2024;177(2):210-20. Bednarczyk L, Reichenpfader D, Gaudet-Blavignac C, Ette AK, Zaghir J, Zheng Y, et al. Scientific evidence for clinical text summarization using large language models: scoping review. J Med Internet Res. 2025;27:e68998. Liu S, McCoy AB, Wright A. Improving large language model applications in biomedicine with retrieval-augmented generation: a systematic review, meta-analysis, and clinical development guidelines. J Am Med Inform Assoc. 2025;32(4):605-15. Baxter SL, Longhurst CA, Millen M, Sitapati AM, Tai-Seale M. Generative artificial intelligence responses to patient messages in the electronic health record: early lessons learned. JAMIA Open. 2024;7(2):ooae028. Chen S, Guevara M, Moningi S, Hoebers F, Elhalawani H, Kann BH, et al. The effect of using a large language model to respond to patient messages. Lancet Digit Health. 2024;6(6):e379-e381. Small WR, Wiesenfeld B, Brandfield-Harvey B, Jonassen Z, Mandal S, Stevens ER, et al. Large language model-based responses to patients' in-basket messages. JAMA Netw Open. 2024;7(7):e2422399. Yan S, Knapp W, Leong A, Kadkhodazadeh S, Das S, Jones VG, et al. Prompt engineering on leveraging large language models in generating response to InBasket messages. J Am Med Inform Assoc. 2024;31(10):2263-70. Hu D, Guo Y, Zhou Y, Flores L, Zheng K. A systematic review of early evidence on generative AI for drafting responses to patient messages. NPJ Health Syst. 2025;2(1):27. Mustafa A, Naseem U, Azghadi MR. Large language models vs human for classifying clinical documents. Int J Med Inform. 2025;195:105800. Subramanian CR, Yang DA, Khanna R. Enhancing health care communication with large language models—the role, challenges, and future directions. JAMA Netw Open. 2024;7(3):e240347. Liu S, Wright AP, Patterson BL, Wanderer JP, Turer RW, Nelson SD, et al. Using AI-generated suggestions from ChatGPT to optimize clinical decision support. J Am Med Inform Assoc. 2023;30(7):1237-45. Liu S, McCoy AB, Wright AP, Nelson SD, Huang SS, Ahmad HB, et al. Why do users override alerts? Utilizing large language model to summarize comments and optimize clinical decision support. J Am Med Inform Assoc. 2024;31(6):1388-96. Heilmeyer F, Böhringer D, Reinhard T, Arens S, Lyssenko L, Haverkamp C. Viability of open large language models for clinical documentation in German health care: real-world model evaluation study. JMIR Med Inform. 2024;12:e59617. Reynolds K, Nadelman D, Durgin J, Ansah-Addo S, Cole D, Fayne R, et al. Comparing the quality of ChatGPT- and physician-generated responses to patients’ dermatology questions in the electronic medical record. Clin Exp Dermatol. 2024;49(7):715-8. Bootsma-Robroeks CM, van Workum JD, Schuit SC, Hoekman A, Mehri T, Doornberg JN, et al. AI-generated draft replies to patient messages: exploring effects of implementation. Front Digit Health. 2025;7:1588143. Williams CY, Subramanian CR, Ali SS, Apolinario M, Askin E, Barish P, et al. Physician- and large language model-generated hospital discharge summaries. JAMA Intern Med. 2025;185(7):818-25. Liu S, Wright AP, McCoy AB, Huang SS, Genkins JZ, Peterson JF, et al. Using large language model to guide patients to create efficient and comprehensive clinical care message. J Am Med Inform Assoc. 2024;31(8):1665-70.