cirpublications.com-eQ0x-1790880681-j510298368 1790880681 Clinical Intelligence Research Press info@cirpublications.com Clinical Intelligence Research Press Journal of Artificial Intelligence for Healthcare Systems J. Artif. Intell. Healthc. Syst. 3149-8981 2025 4 2 Andreas Müller Stefan Weber Julia Hoffmann Lukas Schneider Tobias Klein 2025 10.68159/j510298368 https://cirpublications.com/pub/journal/1/article/j510298368 Thirunavukarasu AJ, Ting DSJ, Elangovan K, Gutierrez L, Tan TF, Ting DSW. Large language models in medicine. Nat Med. 2023;29(8):1930-40. 10.1038/s41591-023-02448-8 Van Veen D, Van Uden S, Blankemeier L, Delbrock H, Wiggins W, Bluethgen C, et al. Adapted large language models can outperform medical experts in clinical text summarization. Nat Med. 2024;30(4):1134-42. 10.1038/s41591-024-02855-5 Hager P, Jungmann F, Holland R, Azam I, Kaiser C, Zinsmeister C, et al. Evaluation and mitigation of the limitations of large language models in clinical decision-making. Nat Med. 2024;30(7):2030-40. 10.1038/s41591-024-03097-1 Riedemann L, Riedemann J, Harms H, Gast BB, Brix TJ, Rühlemann M, et al. The path forward: large language models in medicine. npj Digit Med. 2024;7(1):34. 10.1038/s41746-024-01344-w Peng C, Yang X, Chen A, Smith KE, PourNejatian N, Costa AB, et al. A study of generative large language model for medical research and healthcare. npj Digit Med. 2023;6(1):210. 10.1038/s41746-023-00958-w Mehandru N, Kingsland E, McWilliams CJ, Taylor E, Ershova A, Zhou R, et al. Evaluating large language models as agents in the clinic. npj Digit Med. 2024;7(1):84. 10.1038/s41746-024-01083-y Kather JF. Large language models could make natural language again the universal interface of healthcare. npj Digit Med. 2024;7(1):8. 10.1038/s41746-024-01008-9 Meskó B, Topol EJ. The imperative for regulatory oversight of large language models (or generative AI) in healthcare. npj Digit Med. 2023;6(1):120. 10.1038/s41746-023-00873-0 Clusmann J, Kolbinger FR, Muti HS, Carrero ZI, Haar J, Steiger HJ, et al. The future landscape of large language models in medicine. Commun Med (Lond). 2023;3(1):141. 10.1038/s43856-023-00370-1 Freyer O, Egger J, Schielein T, Biedermann T, Nowack D. A future role for health applications of large language models in the clinical setting? Lancet Digit Health. 2024;6(7):e475-e483. 10.1016/S2589-7500(24)00124-9 Ong JCL, Jayaratne YSN, Vithanarachchi SM, Hamilton A. Ethical and regulatory challenges of large language models in medicine. Lancet Digit Health. 2024;6(6):e428-e432. 10.1016/S2589-7500(24)00061-X Arora A. The promise of large language models in health care. Lancet. 2023;401(10377):641. 10.1016/S0140-6736(23)00216-7 de Hond A, van der Gaag M, van Harmelen F. From text to treatment: the crucial role of validation for generative large language models in health care. Lancet Digit Health. 2024;6(5):e311-e312. 10.1016/S2589-7500(24)00111-0 Chen S, Kann BH, Foote MB, Aerts HJWL, Savova GK, Mak RH, et al. The effect of using a large language model to respond to patient messages. Lancet Digit Health. 2024;6(6):e379-e384. 10.1016/S2589-7500(24)00060-8 Harrer S. Attention is not all you need: the complicated case of ethically using large language models in healthcare and medicine. eBioMedicine. 2023;90:104512. 10.1016/j.ebiom.2023.104512 Du X, Eshraghian JK, Gallego B, Chen Z, Vitale F, Skafidas E. Enhancing early detection of cognitive decline in the elderly: a comparative study utilizing large language models in clinical notes. eBioMedicine. 2024;107:105297. 10.1016/j.ebiom.2024.105297 Bedi S, Gallo R, Spadaro B, Arabadjian M, Weingarten J, Haggstrom L, et al. Testing and evaluation of health care applications of large language models: a systematic review. JAMA. 2024;332(13):1091-100. 10.1001/jama.2024.16502 Goh E, Gallo R, Hom J, Strong E, Weng Y, Kerman J, et al. Large language model influence on diagnostic reasoning: a randomized clinical trial. JAMA Netw Open. 2024;7(10):e2440900. 10.1001/jamanetworkopen.2024.40900 Wei J, Wang X, Schuurmans D, Bosma M, Xia F, Chi E, et al. Chain-of-thought prompting elicits reasoning in large language models. Adv Neural Inf Process Syst. 2022;35:24824-37. Williams CYK, Sinsky C, Haq C, Sattler A, Linzer M. Physician- and large language model–generated hospital discharge summaries. JAMA Intern Med. 2024;184(3):327-34. 10.1001/jamainternmed.2023.7328 Williams CYK, Zack T, Miao BY, Sushytskyi I, Tabaie A, Baltusis BS, et al. Use of a large language model to assess clinical acuity of adults in the emergency department. JAMA Netw Open. 2024;7(5):e248895. 10.1001/jamanetworkopen.2024.8895 Huo B, Theodorou B, Sorkhei M, Song S, Christensen E, McKeever J, et al. Large language models for chatbot health advice studies: a systematic review. JAMA Netw Open. 2024;7(5):e2412665. 10.1001/jamanetworkopen.2024.12665 Subramanian CR, Grossberg AJ. Enhancing health care communication with large language models—the role, challenges, and future directions. JAMA Netw Open. 2024;7(3):e241587. 10.1001/jamanetworkopen.2024.1587 Ranji SR. Large language models—misdiagnosing diagnostic excellence? JAMA Netw Open. 2024;7(10):e2440901. 10.1001/jamanetworkopen.2024.40901 Shah NH, Entwistle D, Pfeffer MA. Creation and adoption of large language models in medicine. JAMA. 2023;330(9):866-9. 10.1001/jama.2023.14217 Lee RW, Lee JK, Lee JS. Vulnerability of large language models to prompt injection when providing medical advice. JAMA Netw Open. 2024;7(9):e2432987. 10.1001/jamanetworkopen.2024.32987 Zou S, Chen Y, Liang H, Li W, Chen Y. Large language models in the healthcare: a review. IEEE J Biomed Health Inform. 2024;28(4):2095-106. 10.1109/JBHI.2024.3357404 Abdulnazar A. Large language models for clinical text cleansing enhance medical concept normalization. J Biomed Inform. 2024;151:104599. 10.1016/j.jbi.2024.104599 Huang J, Chang KC. Towards reasoning in large language models: a survey. Findings Assoc Comput Linguist ACL. 2023:1049-65.