<?xml version="1.0" encoding="UTF-8"?><doi_batch version="4.3.7" xmlns="http://www.crossref.org/schema/4.3.7" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.crossref.org/schema/4.3.7 http://www.crossref.org/schema/deposit/crossref4.3.7.xsd">
		<head>
		<doi_batch_id>cirpublications.com-PVzL-1790880681-b246057097</doi_batch_id>
		<timestamp>1790880681</timestamp>
		<depositor>
			<depositor_name>Clinical Intelligence Research Press</depositor_name>
			<email_address>info@cirpublications.com</email_address>
		</depositor>
		<registrant>Clinical Intelligence Research Press</registrant>
	</head>
	<body>
		<journal>
			<journal_metadata>
				<full_title>Journal of Artificial Intelligence for Healthcare Systems</full_title>
				<abbrev_title>J. Artif. Intell. Healthc. Syst.</abbrev_title>
				<issn>3149-8981</issn>
			</journal_metadata>
			<journal_issue>
				<publication_date>
					<year>2024</year>
				</publication_date>
				<journal_volume>
					<volume>3</volume>
				</journal_volume>
				<issue>2</issue>
			</journal_issue>
			<journal_article publication_type="full_text">
				<titles>
					<title>From Protocols to Preferences: Why Reinforcement Learning from Human Feedback Must Replace Fixed Weaning Protocols for Prolonged Mechanical Ventilation</title>
				</titles>
								<contributors>
          					<person_name sequence="first" contributor_role="author">
            <given_name>Luis</given_name>
            <surname>Herrera</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Daniela</given_name>
            <surname>Rojas</surname>
					</person_name>
          					<person_name sequence="additional" contributor_role="author">
            <given_name>Andres</given_name>
            <surname>Castro</surname>
					</person_name>
          				</contributors>
								<publication_date>
					<year>2024</year>
				</publication_date>
				<doi_data>
					<doi>10.68159/b246057097</doi>
					<resource>https://cirpublications.com/pub/journal/1/article/b246057097</resource>
				</doi_data>
				<citation_list>
          					<citation key="rk-10.68159/b246057097-613e6db5-9d62-42e8-9577-8ebbc0bbe345">
					  <unstructured_citation>Christiano PF, Leike J, Brown T, Martic M, Legg S, Amodei D. Deep reinforcement learning from human preferences. Adv Neural Inf Process Syst. 2017;30.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-46fe0b64-f72f-4002-8d1c-577659098759">
					  <unstructured_citation>Stiennon N, Ouyang L, Wu J, Ziegler D, Lowe R, Voss C, et al. Learning to summarize with human feedback. Adv Neural Inf Process Syst. 2020;33:3008-21.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-9ad45ae6-92d6-4ff1-adf8-af992a99da65">
					  <unstructured_citation>Ouyang L, Wu J, Jiang X, Almeida D, Wainwright C, Mishkin P, et al. Training language models to follow instructions with human feedback. Adv Neural Inf Process Syst. 2022;35:27730-44.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-85655dd5-ab35-4fe9-bb27-6aaeb9b20763">
					  <unstructured_citation>Sendak M, Elish MC, Gao M, Futoma J, Ratliff W, Nichols M, et al. “The human body is a black box”: supporting clinical decision-making with deep learning. In: Proc 2020 Conf Fairness Accountability Transparency. 2020. p. 99-109.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-c83bfaad-b63c-4dc4-8767-729f0fa97adc">
					  <unstructured_citation>Yu C, Liu J, Zhao H. Inverse reinforcement learning for intelligent mechanical ventilation and sedative dosing in intensive care units. BMC Med Inform Decis Mak. 2019;19(Suppl 2):57.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-c1057d3f-5196-4cdb-b585-de53a92b899d">
					  <unstructured_citation>Yu C, Ren G, Dong Y. Supervised-actor-critic reinforcement learning for intelligent mechanical ventilation and sedative dosing in intensive care units. BMC Med Inform Decis Mak. 2020;20(Suppl 3):124.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-392c7c3b-f9bf-4712-8a0a-56eef472ec59">
					  <unstructured_citation>Huang HY, Huang CY, Li LF. Prolonged mechanical ventilation: outcomes and management. J Clin Med. 2022;11(9):2451.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-1d32d67f-cab8-4499-888d-e6c8f443d6b5">
					  <unstructured_citation>den Hengst F, Otten M, Elbers P, van Harmelen F, François-Lavet V, Hoogendoorn M. Guideline-informed reinforcement learning for mechanical ventilation in critical care. Artif Intell Med. 2024;147:102742.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-3cef2194-cf44-44b3-a136-e3e0f041ccec">
					  <unstructured_citation>Roggeveen LF, Hassouni AE, de Grooth HJ, Girbes AR, Hoogendoorn M, Elbers PW, et al. Reinforcement learning for intensive care medicine: actionable clinical insights from novel approaches to reward shaping and off-policy model evaluation. Intensive Care Med Exp. 2024;12(1):32.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-a2f86291-bd99-436d-97a5-87f3965cd622">
					  <unstructured_citation>Burns KEA, Rochwerg B, Seely AJ. Ventilator weaning and extubation. Crit Care Clin. 2024;40(2):391-408.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-88f254ed-1455-44bf-a9b2-4785788913b8">
					  <unstructured_citation>Lin MY, Li CC, Lin PH, Wang JL, Chan MC, Wu CL, et al. Explainable machine learning to predict successful weaning among patients requiring prolonged mechanical ventilation: a retrospective cohort study in central Taiwan. Front Med (Lausanne). 2021;8:663739.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-35d903a6-7a85-4fc9-83ca-e2e88badc0d9">
					  <unstructured_citation>Marshall DC, Komorowski M. Is artificial intelligence ready to solve mechanical ventilation? Computer says blow. Br J Anaesth. 2022;128(2):231-3.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-b1f6f050-a667-46c0-9959-f3be0fdb77ed">
					  <unstructured_citation>Jhou HJ, Chen PH, Ou-Yang LJ, Lin C, Tang SE, Lee CH. Methods of weaning from mechanical ventilation in adult: a network meta-analysis. Front Med (Lausanne). 2021;8:752984.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-64f14430-c2bb-47ec-bd4d-d68c039a3afa">
					  <unstructured_citation>Misseri G, Piattoli M, Cuttone G, Gregoretti C, Bignami EG. Artificial intelligence for mechanical ventilation: a transformative shift in critical care. Ther Adv Pulm Crit Care Med. 2024;19:29768675241298918.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-9fa9f356-0e17-49ce-aae5-5e6286bb81fd">
					  <unstructured_citation>Balagopalan A, Baldini I, Celi LA, Gichoya J, McCoy LG, Naumann T, et al. Machine learning for healthcare that matters: reorienting from technical novelty to equitable impact. PLOS Digit Health. 2024;3(4):e0000474.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-cb1baa04-cbaf-4bb3-a8e5-cf82e903cedd">
					  <unstructured_citation>Sblendorio E, Dentamaro V, Cascio AL, Germini F, Piredda M, Cicolini G. Integrating human expertise and automated methods for a dynamic and multi-parametric evaluation of large language models’ feasibility in clinical decision-making. Int J Med Inform. 2024;188:105501.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-b79be9f3-273c-4145-9360-57bbfa2f6e78">
					  <unstructured_citation>Lee CS, Chen NH, Chuang LP, Chang CH, Li LF, Lin SW, et al. Hypercapnic ventilatory response in the weaning of patients with prolonged mechanical ventilation. Can Respir J. 2017;2017(1):7381424.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-477a5402-2869-452f-8c5a-81944add9c41">
					  <unstructured_citation>Ghiani A, Paderewska J, Sainis A, Crispin A, Walcher S, Neurohr C. Variables predicting weaning outcome in prolonged mechanically ventilated tracheotomized patients: a retrospective study. J Intensive Care. 2020;8(1):19.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-b43674bc-b81a-42ed-b57b-0fd0b8217805">
					  <unstructured_citation>Liao KM, Ko SC, Liu CF, Cheng KC, Chen CM, Sung MI, et al. Development of an interactive AI system for the optimal timing prediction of successful weaning from mechanical ventilation for patients in respiratory care centers. Diagnostics (Basel). 2022;12(4):975.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-dec759d9-7cc2-4a14-82eb-3b1b5eede4e6">
					  <unstructured_citation>Cheng KH, Tan MC, Chang YJ, Lin CW, Lin YH, Chang TM, et al. The feasibility of a machine learning approach in predicting successful ventilator mode shifting for adult patients in the medical intensive care unit. Medicina (Kaunas). 2022;58(3):360.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-7dd9ff48-1f42-4d10-9a93-f96347cf6824">
					  <unstructured_citation>Park JE, Kim TY, Jung YJ, Han C, Park CM, Park JH, et al. Biosignal-based digital biomarkers for prediction of ventilator weaning success. Int J Environ Res Public Health. 2021;18(17):9229.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-ed0bc30d-965d-4f3b-8ab2-58a204a8fffc">
					  <unstructured_citation>Park JE, Kim DY, Park JW, Jung YJ, Lee KS, Park JH, et al. Development of a machine learning model for predicting weaning outcomes based solely on continuous ventilator parameters during spontaneous breathing trials. Bioengineering (Basel). 2023;10(10):1163.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-8c42d69e-10bb-4fcd-a64c-d2c17cdafaa8">
					  <unstructured_citation>Pai KC, Su SA, Chan MC, Wu CL, Chao WC. Explainable machine learning approach to predict extubation in critically ill ventilated patients: a retrospective study in central Taiwan. BMC Anesthesiol. 2022;22(1):351.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-e6b6501f-8847-4a3f-a581-377a86d7f2e8">
					  <unstructured_citation>Sheikhalishahi S, Kaspar M, Zaghdoudi S, Sander J, Simon P, Geisler BP, et al. Predicting successful weaning from mechanical ventilation by reduction in positive end-expiratory pressure level using machine learning. PLOS Digit Health. 2024;3(3):e0000478.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-51ebc45d-71f3-4a95-a1a4-3a63350465b7">
					  <unstructured_citation>Huang KY, Hsu YL, Chen HC, Horng MH, Chung CL, Lin CH, et al. Developing a machine-learning model for real-time prediction of successful extubation in mechanically ventilated patients using time-series ventilator-derived parameters. Front Med (Lausanne). 2023;10:1167445.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-20f2c687-a352-431f-889e-a7baa3f685b5">
					  <unstructured_citation>Jia Y, Kaul C, Lawton T, Murray-Smith R, Habli I. Prediction of weaning from mechanical ventilation using convolutional neural networks. Artif Intell Med. 2021;117:102087.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-01ccfb46-6bf6-4c23-89aa-721556742279">
					  <unstructured_citation>Torrini F, Gendreau S, Morel J, Carteaux G, Thille AW, Antonelli M, et al. Prediction of extubation outcome in critically ill patients: a systematic review and meta-analysis. Crit Care. 2021;25(1):391.</unstructured_citation>
											</citation>
          					<citation key="rk-10.68159/b246057097-24f65378-3436-4d91-b649-9dd442a12b82">
					  <unstructured_citation>Leonov Y, Kisil I, Perlov A, Stoichev V, Ginzburg Y, Nazarenko A, et al. Predictors of successful weaning in patients requiring extremely prolonged mechanical ventilation. Adv Respir Med. 2020;88(6):477-84.</unstructured_citation>
											</citation>
          				</citation_list>
			</journal_article>
		</journal>
	</body>
</doi_batch>
